This module of dPABBs allows the user to submit a single peptide sequence and generates all possible mutants thereof via successive amino acid substitutions at each position for further optimisation of the peptide's activity against bacterial biofilms. It also predicts whether this peptide and its mutants are biofilm-active or inactive, employing the SVM/Weka-based model specified by the user. The desired physicochemical properties (such as hydrophobicity, charge, hydrophilicity etc.) can also be selected and are displayed accordingly.

Paste peptide sequence (amino acids single leter code) :

Select model:   SVM based: Whole amino acid composition (Whole AAC)   Selected 14 residue-composition (Sel_14_res)    NT5 residue-binary pattern profile (NT5 BPP)   WEKA based: Whole amino acid composition (Whole AAC)   Selected 8 residue-composition (Sel_8_res)    NT5 residue-binary pattern profile (NT5 BPP)

SVM threshold:    -1.0 -0.9 -0.8 -0.7 -0.6 -0.5 -0.4 -0.3 -0.2 -0.1 0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0

Physicochemical property: Check / Uncheck All